ABSTRACT
Objective To investigate the effect of Yiqihuayu herb on serum NF-κB p65 and myocardin in patients with hysteromyoma. Methods 56 cases patients with hysteromyoma were selected and divided into two groups.The control group of 28 cases were treated with mifepristone, and the experiment group of 28 cases were treated with Yiqihuayu herb.The clinical curative effect, uterine myoma volume, expression of NF-κB p65 and myocardin level were compared after treatment.Results The clinical curative effect of the experiment group was 89.29%, which was higher than 67.86% of control group(χ2 =3.82,P<0.05).Compared with control group, NF-κB p65 expression level was lower(P<0.05), myocardin expression level was higher ( P<0.05 ) , the volume of uterus and uterine myoma were smaller ( P<0.05 ) .Conclusion Yiqihuayu recipe could reduce the expression of NF-κB p65 in serum, increase myocardin level, and reduce the volume of uterus and myoma, which has good clinical curative effect in the treatment of patients with hysteromyoma.
ABSTRACT
Objective To investigate effect serum Bcl-2 and Bax in patients with myoma of uterus by Jiang Sanqi.Methods 92 patients with uterine fibroids were selected,and randomly divided into experiment group and control group.Control group of 46 cases treated with goserelin once 3.6 mg every month,subcutaneous injection,mifepristone 12.5 mg,once a day for oral treatment.Experiment group of 46 cases treated with Jiang Sanqi,0.5 g/kg,once a day for boiling water, for 3 months.The level of Bcl-2 and Bax in serum, clinical efficiency, diameter of tumor and complications were compared after treatment.Results The levels of Bcl-2 of experimental group patients was lower than control group, the level of Bax was higher than that of the control group (P<0.05).The total efficiency of experimental group(89.13%)was higher than that of the control group(71.74)%(P<0.05). The experimental group tumor diameter was smaller than the control group(P<0.05).Complications of the experiment was lower than the control group (P<0.05).Conclusion Jiang Sanqi can significantly reduce the serum Bcl-2 of patients with uterine fibroids,increase the expression level of Bax, reduce the uterine fibroids diameter effect, reduce the incidence rate of hormone suppression of drug side effects, has a great significance in clinical.